Bhardwaj, Priya and Bisht, Bhawana and Bhalla, Vijayender (2025) Nanoscale size impact of nanoparticle interaction and activity studies with urease. Nanoscale, 17. pp. 5000-5004.
Full text not available from this repository.Abstract
Herein, we provide insights into the size-dependent interactions of silver nanoparticles (AgNPs) with urease and their implications for enzyme inhibition. AgNPs with a size of 5 nm exhibited the strongest binding affinity of 66 nM, resulting in significant enzyme attachment, interfering enzyme conformation, and a consequent loss of activity. Mid-sized AgNPs, i.e., 20 and 50 nm, exhibited binding affinities of 712 and 616 nM, causing only slight structural alterations. In contrast, 100 nm AgNPs demonstrated a high binding affinity of 171 nM accompanied by a favorable enthalpic contribution and a pronounced inhibitory effect.
| Item Type: | Article |
|---|---|
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 01 Feb 2026 03:03 |
| Last Modified: | 01 Feb 2026 03:03 |
| URI: | http://crdd.osdd.net/open/id/eprint/3202 |
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