Chhabra, Sonali and Parkesh, Raman (2025) A dual-function probe for inhibition and rapid detection of Mycobacterium tuberculosis. Chem. Commun., 61. pp. 12123-12126.
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Official URL: http://dx.doi.org/10.1039/D5CC02317C
Abstract
We introduce a dual-purpose solvatochromic naphthalimide-benzothiazinone (BTZ) conjugate with theranostic potential that enables specific and rapid detection of Mycobacterium tuberculosis by targeting the DprE1 enzyme, while also exhibiting antimicrobial activity. The photoinduced electron transfer (PeT)-based fluorophore incorporates into the mycobacterial cell wall, producing detectable fluorescence within 15 minutes and thus, highlighting its suitability for rapid, point-of-care TB detection in low-resource settings.
| Item Type: | Article |
|---|---|
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 02 Feb 2026 07:23 |
| Last Modified: | 02 Feb 2026 07:23 |
| URI: | http://crdd.osdd.net/open/id/eprint/3210 |
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