Khajuria, Akhil and Alajangi, Hema K and Sharma, Akanksha and Kaur, Harinder and Sharma, Prakriti and Negi, Sushmita and Kumari, Laxmi and Trivedi, Manisha and Yadav, Ashok Kumar and Kumar, Robin and Raghuvanshi, Rajeev Singh and Kaur, Indu Pal and Tyagi, Rajeev K and Jaiswal, Pradeep Kumar and Lim, Yong-Beom and Barnwal, Ravi Pratap and Singh, Gurpal (2024) Theranostics: aptamer-assisted carbon nanotubes as MRI contrast and photothermal agent for breast cancer therapy. Discov. Nano, 19 (1). p. 145.
Full text not available from this repository.Abstract
Breast cancer is one of the leading causes of death among women globally, making its diagnosis and treatment challenging. The use of nanotechnology for cancer diagnosis and treatment is an emerging area of research. To address this issue, multiwalled carbon nanotubes (MWCNTs) were ligand exchanged with butyric acid (BA) to gain hydrophilic character. The successful functionalization was confirmed by FTIR spectroscopy. Surface morphology changes were observed using SEM, while TEM confirmed the structural integrity of the MWCNTs after functionalization. Particle size, zeta potential, and UV spectroscopy were also performed to further characterize the nanoparticles. The breast cancer aptamer specific to Mucin-1 (MUC-1) was then conjugated with the functionalized MWCNTs. These MWCNTs successfully targeted breast cancer cells (MDA-MB-231) as examined by cellular uptake studies and exhibited a reduction in cancer-induced inflammation, as evidenced by gene transcription (qPCR) and protein expression (immunoblotting) levels. Immunoblot and confocal-based immunofluorescence assay (IFA) indicated the ability of CNTs to induce photothermal cell death of MDA-MB-231 cells. Upon imaging, cancer cells were effectively visualized due to the MWCNTs' ability to act as magnetic resonance imaging (MRI) contrast agents. Additionally, MWCNTs demonstrated photothermal capabilities to eliminate bound cancer cells. Collectively, our findings pave the way for developing aptamer-labeled MWCNTs as viable ``theranostic alternatives'' for breast cancer treatment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Aptamer; Breast cancer; MWCNT; Mucin; Nanotechnology; Theranostics |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 07 Feb 2026 04:31 |
| Last Modified: | 07 Feb 2026 04:31 |
| URI: | http://crdd.osdd.net/open/id/eprint/3319 |
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