Sharma, Yogesh and Pawar, Ganesh P and Chaudhari, Vinod D (2023) One-pot domino reaction: Direct access to polysubstituted 1,4-benzothiazine 1,1-dioxide via water-gas shift reaction utilizing DMF/H2O. J. Org. Chem., 88 (1). pp. 701-710.
Full text not available from this repository. (Request a copy)Abstract
Benzothiazine 1,1-dioxide (BTDO) is a privileged chemical motif, and its metal-free domino access is in high demand. Current BTDO production methods require costly metal catalysts or harsh reaction conditions. A facile domino approach to BTDO via a water-gas shift reaction (WGSR) employing sodium 2-nitrobenzenesulfinates and α-bromo ketones is presented. This strategy is cost-effective and environmentally beneficial. The optimized reaction conditions demonstrated remarkable chemical tolerance to a wide range of electrically and sterically varied substituents on both coupling partners.
| Item Type: | Article |
|---|---|
| Additional Information: | copyright of this article belongs to American Chemical Society (ACS) |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 25 Mar 2026 06:54 |
| Last Modified: | 25 Mar 2026 06:54 |
| URI: | http://crdd.osdd.net/open/id/eprint/3394 |
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