Shikha, Sristy and Kumar, Vineet and Jain, Ankita and Dutta, Dipak and Bhattacharyya, Mani Shankar (2023) Unraveling the mechanistic insights of sophorolipid-capped gold nanoparticle-induced cell death in Vibrio cholerae. Microbiol. Spectr., 11 (6). e0017523.
Full text not available from this repository. (Request a copy)Abstract
IMPORTANCE: Vibrio cholerae, a Gram-negative bacterium, is the causative agent of a fatal disease, ``cholera.'' Prevention of cholera outbreak is possible by eliminating the bacteria from the environment. However, antimicrobial resistance developed in microorganisms has posed a threat and challenges to its treatment. Application of nanoparticles is a useful and effective option for the elimination of such microorganisms. Metal-based nanopaticles exhibit microbial toxicity through non-specific mechanisms. To prevent resistance development and increase antibacterial efficiency, rational designing of nanoparticles is required. Thus, knowledge on the exact mechanism of action of nanoparticles is highly essential. In this study, we explore the possible mechanisms of antibacterial activity of AuNPs-SL against V. cholerae. We show that the interaction of AuNPs-SL with V. cholerae enhances ROS production and membrane depolarization, change in permeability, and leakage of intracellular content. This action leads to the depletion of cellular ATP level, DNA damage, and subsequent cell death.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to American Society for Microbiology |
| Uncontrolled Keywords: | DNA fragmentation; ROS; Vibrio cholerae; apoptosis; membrane damage; oxidative stress; sophorolipid-capped gold nanoparticles |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 25 Mar 2026 07:00 |
| Last Modified: | 25 Mar 2026 07:00 |
| URI: | http://crdd.osdd.net/open/id/eprint/3395 |
Actions (login required)
 |
View Item |
