Identification of the INO1 gene of Mycobacterium tuberculosis H37Rv reveals a novel class of inositol-1-phosphate synthase enzyme.

Bachhawat, N and Mande, S C (1999) Identification of the INO1 gene of Mycobacterium tuberculosis H37Rv reveals a novel class of inositol-1-phosphate synthase enzyme. Journal of molecular biology, 291 (3). pp. 531-6. ISSN 0022-2836

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Abstract

1L-myo-inositol (inositol) is vital for the biogenesis of mycothiol, phosphatidylinositol and glycosylphosphatidylinositol anchors linked to complex carbohydrates in Mycobacterium tuberculosis. All these cellular components are thought to play important roles in host-pathogen interactions and in the survival of the pathogen within the host. However, the inositol biosynthetic pathway in M. tuberculosis is not known. To delineate the pathways for inositol formation, we employed a unique combination of tertiary structure prediction and yeast-based functional assays. Here, we describe the identification of the gene for mycobacterial INO1 that encodes inositol-1-phosphate synthase distinct in many respects from the eukaryotic analogues.

Item Type:	Article
Additional Information:	Copyright of this article belongs to Academic Press/Elsevier
Uncontrolled Keywords:	INO1; inositol-1-phosphate synthase; inositol; Mycobacterium tuberculosis; sequence threading
Subjects:	Q Science > QR Microbiology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	03 Jan 2012 16:49
Last Modified:	03 Jan 2012 16:49
URI:	http://crdd.osdd.net/open/id/eprint/340

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