@ARTICLE{Negi2026-en,
  title     = "Candida auris: a multidimensional focus on its identification,
               epidemiology, pathogenesis, and therapeutic options",
  author    = "Negi, Preeti and Verma, Nandini and Rishi, Praveen and Multani,
               Kanika and Sharma, Milani and Kumari, Seema and Raj, Khem",
  abstract  = "Humans have encountered many epidemics caused by pathogenic
               microorganisms since the turn of the century. The prevalence of
               fungal infections has significantly increased on a global scale,
               adversely impacting human health. Candida species remain among
               the most prevalent and widely spread opportunistic fungi, with
               Candida auris emerging as a notorious hospital-acquired
               pathogen. This fungal pathogen causes nosocomial bloodstream
               infections (BSI), coupled with a high in-hospital death rate and
               significant multidrug-resistance (MDR). Standard quaternary
               ammonium compounds (Quats), are often ineffective, requiring the
               use of Environmental Protection Agency (EPA)-registered
               hospital-grade disinfectants. Routine laboratory procedures
               often fail to efficiently identify the fungi, making it
               difficult to predict the infection's true severity. Hence,
               molecular-based methods are now considered the gold standard for
               rapid identification. Despite the availability of approved
               drugs, their efficacy is questionable due to the emerging drug
               resistance within the fungal population. The organism appears to
               acquire drug resistance quickly. While echinocandins remain
               first-line therapy, the emergence of echinocandin-or
               pan-resistant cases indicates that treating pan-resistant
               strains would be particularly tricky, if not unfeasible. This
               underscores the urgent need for enhanced infection control,
               improved point-of-care diagnostics, and the development of novel
               therapeutic strategies. This article highlights the crucial
               aspects of epidemiology, identification techniques, drug
               resistance mechanisms, treatments, and challenges associated
               with C. auris infections. Understanding these interconnected
               aspects is essential for optimizing clinical management and
               mitigating the escalating public health crisis posed by this
               tenacious pathogen.",
  journal   = "Arch. Microbiol.",
  publisher = "Springer Science and Business Media LLC",
  volume    =  208,
  number    =  6,
  month     =  apr,
  year      =  2026,
  keywords  = "Candida auris infection; Antifungal; Epidemiology; Infection
               control; Novel therapies; Pan-resistance; Pathogenesis;
               Prevalence; Resistance mechanism",
  copyright = "https://www.springernature.com/gp/researchers/text-and-data-mining",
  language  = "en"
}