@ARTICLE{Gupta2026-qu,
  title     = "Ovarian {Rev-erb$\alpha$}: a central regulator of fertility
               following chronodisruption",
  author    = "Gupta, Shalini and Kumawat, Saumyata and Kaushal, Vipashu and
               Arora, Rashmi and Kumar, Sumit and Sharma, Rahul and Bhardwaj,
               Anshu and Khatri, Neeraj and Gupta, Pawan",
  abstract  = "Introduction: Circadian rhythm disruption caused by shift work,
               nutritional imbalance, and the stresses of modern life can alter
               hormone secretion, lead to menstrual irregularities, impair
               follicle development, and contribute to ovarian hypoplasia. The
               mechanistic role of circadian rhythm disruption in reproductive
               disorders has been thoroughly investigated. Nuclear receptors
               are known to play an important role in female reproduction and
               in maintaining pregnancy. Rev-erb$\alpha$, a circadian nuclear
               receptor, is a key component of the circadian clock and helps
               sustain circadian rhythm. Materials and Methods: We evaluated
               the potential prophylactic and therapeutic functions of
               Rev-erb$\alpha$ in supporting female fertility by orchestrating
               a series of events that culminate in successful pregnancy. We
               generated a circadian rhythm-disrupted female mouse model to
               study fertility. Results: The Rev-erb$\alpha$ ligand SR9011
               improved the fertility index in these circadian rhythm-disrupted
               female mice. Moreover, SR9011 treatment restored impaired
               ovarian follicular cell proliferation and division, regulated
               steroidogenesis and steroid hormone production, enhanced
               progesterone and melatonin secretion, and mitigated the adverse
               effects of circadian disruption on folliculogenesis. SR9011 also
               reduced follicular atresia and promoted follicle development in
               CR-disrupted mice. Rev-erb$\alpha$ is a key regulator
               influencing oocyte retrieval, as demonstrated in mice treated
               with the Rev-erb$\alpha$ antagonist SR8278.
               Discussion/Conclusion: These findings suggest that targeting
               Rev-erb$\alpha$ signaling and elucidating its mechanistic role
               in female reproduction could inform the development of more
               effective strategies for treating female infertility. As a
               sought-after druggable target, Rev-erb$\alpha$ has a broad range
               of potential therapeutic applications and has recently attracted
               considerable attention in the context of female infertility
               treatment.",
  journal   = "Front. Endocrinol. (Lausanne)",
  publisher = "Frontiers Media SA",
  volume    =  17,
  number    =  1742988,
  pages     = "1742988",
  month     =  feb,
  year      =  2026,
  keywords  = "REV-ERB$\alpha$; clock genes; folliculogenesis; superovulation;
               therapeutic",
  copyright = "https://creativecommons.org/licenses/by/4.0/",
  language  = "en"
}