@ARTICLE{Sen2026-dt,
  title     = "Comprehensive findings of functional modulations linked to
               structural intricacies in {DNA} binding for {HapR/LuxR}
               homologues from the Vibrionaceae family",
  author    = "Sen, Himanshu and Choudhury, Gourab Basu and Das, Joyasree and
               Surin, Shradha and Ekka, Manjula and Saha, Angira and Saha,
               Debayan and Krishnamurthi, Srinivasan and Datta, Saumen and
               Raychaudhuri, Saumya",
  abstract  = "LuxR/HapR homologues play important roles in the regulation of
               virulence and protease genes in pathogenic Vibrio species like
               V. cholerae, V. vulnificus, V. parahaemolyticus, etc. as well as
               providing physiological advantages such as resistance to
               protozoan grazing, motility and chitin-induced competence in the
               aqueous environments. They are commonly termed as the high cell
               density master regulators. They are highly conserved in sequence
               and structure among the Vibrios and can recognize and bind to
               common DNA promoters, like activation of protease production in
               V. cholerae by SmcR of V. vulnificus. Despite this conservation,
               critical differences occur due to amino acid divergence in their
               sequences. In the present study, we compare the degree of
               functional conservation among HapR/LuxR homologues selected from
               various clades of the Vibrionaceae family, using a hapR mutant
               V. cholerae strain as a model organism. We also delve into the
               structural intricacies of distant HapR/LuxR homologues, such as
               LuxR proteins of Photobacterium spp. and HapR of Vibrio mimicus,
               a close homologue of V. cholerae. Evolutionary implications
               arising from sequence divergence are also recorded in the
               structural changes through the crystal structure analysis. The
               study compared several structural constraints responsible for
               the variation in functions related to transcriptional
               regulation.",
  journal   = "Int. J. Biol. Macromol.",
  publisher = "Elsevier BV",
  volume    =  348,
  number    =  150722,
  pages     = "150722",
  month     =  mar,
  year      =  2026,
  keywords  = "Crystal structure; HapR/LuxR; Quorum sensing; Transcriptional
               regulators; Vibrionaceae",
  copyright = "http://creativecommons.org/licenses/by/4.0/",
  language  = "en"
}