Association of Mycobacterium avium paratuberculosis With Crohn's Disease: A Large Multicenter Study From a Tuberculosis-Endemic Region

Vuyyuru, Sudheer Kumar and Singh, Urvashi and Das, Prasenjit and Basant, Shiv and Singh, Vishwajeet and Sinha, Saroj Kant and Sharma, Kusum and Ramakrishnan, B S and Palaniyandi, Kannan and Pokharna, Rupesh and Malhotra, Bharti and Bhatia, Shobna and Dhali, Gopal Krishna and Sarkar, Rajib and Sharma, Charu and Dattagupta, Siddhartha and Singh, Manjula and Kochhar, Rakesh and Vishnubhatla, Sreenivas and Ahuja, Vineet (2026) Association of Mycobacterium avium paratuberculosis With Crohn's Disease: A Large Multicenter Study From a Tuberculosis-Endemic Region. Clin. Infect. Dis., 82 (5). pp. 841-847.

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Abstract

BackgroundThe causal relationship between Crohn's disease (CD) and Mycobacterium avium subspecies paratuberculosis (MAP) remains controversial.MethodsThis multicenter observational study was conducted across seven tertiary care centers in India enrolled newly diagnosed, treatment-na\"\ive Crohn's disease (CD) patients as cases, and treatment-na\"\ive intestinal tuberculosis (ITB), ulcerative colitis (UC), and healthy individuals undergoing sigmoidoscopy for hemorrhoids as controls. Mycobacterium avium subspecies paratuberculosis (MAP) detection was performed using serology for MAP antibodies, PCR, RT-qPCR, and solid/liquid cultures on blood and colonic biopsies. In situ PCR and immunohistochemistry (IHC) were additionally applied to paraffin-embedded tissue sections to evaluate MAP presence across groups.FindingsA total of 889 participants were recruited (CD=148, ITB=288, UC=251 and non-IBD controls=202) were included. The seropositivity of MAP was significantly higher in patients with CD compared to controls (20.6% 13/63 vs healthy controls: 16.2\% 12/74; ITB: 7.8\% 9/116; UC: 4.8\% 4/84; pInterpretationFindings of our study suggest an increased association of MAP and CD. Future studies should explore possible causal role of MAP in CD and potential therapeutic options to target MAP.

Item Type:	Article
Additional Information:	Copyright of this article belongs to Oxford University Press (OUP)
Uncontrolled Keywords:	Mycobacterium avium paratuberculosis ; Crohn's disease; intestinal tuberculosis; ulcerative colitis
Subjects:	Q Science > QR Microbiology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	22 Jul 2026 05:54
Last Modified:	22 Jul 2026 05:54
URI:	http://crdd.osdd.net/open/id/eprint/3489

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