Shaji, A V and Kulkarni, S K and Agrewala, J N (1998) Regulation of secretion of IL-4 and IgG1 isotype by melatonin-stimulated ovalbumin-specific T cells. Clinical and experimental immunology, 111 (1). pp. 181-5. ISSN 0009-9104
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Abstract
In the present study, we describe the potential role of melatonin, a pineal hormone, in regulating the activation of the antigen-specific T cell response. Melatonin encouraged the proliferation of Th cells and improved their ability to secrete IL-4, but down-regulated the levels of IL-2 and interferon-gamma (IFN-gamma). Melatonin, however, could not exert any influence on the T cells of unprimed mice. On studying the regulation of subclass of IgG isotype, melatonin specifically enhanced the secretion of antigen-specific IgG1 antibodies and decreased the yield of IgG2a isotype. The results suggest that melatonin possibly acts by selectively activating a Th2-like immune response.
| Item Type: | Article |
|---|---|
| Additional Information: | copyright of this article belongs Blackwell/Oxford |
| Uncontrolled Keywords: | melatonin;T cell;IL-4 and IgG1 |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 02 Jan 2012 17:27 |
| Last Modified: | 02 Jan 2012 17:27 |
| URI: | http://crdd.osdd.net/open/id/eprint/361 |
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