Strategies for production of a potential candidate vaccine for cholera.

Ghosh, A and Thungapathra, M and Ghosh, R K (1996) Strategies for production of a potential candidate vaccine for cholera. The Indian journal of medical research, 104. pp. 60-75. ISSN 0971-5916

Full text not available from this repository. (Request a copy)


First attempt at cholera vaccination was made by Jaime Ferran in 1884. Since then, a variety of strategies and methods have been evolved to create a safe, efficacious vaccine against cholera. For the first few years emphasis was on the development of parenteral vaccines. However, as a result of accumulation of a tremendous amount of knowledge, not only on Vibrio cholerae-the causative agent, but also on its interaction with the host, emphasis has shifted towards the development of oral vaccines. Two such vaccines, one killed, a whole cell/B subunit combination vaccine and the other a live attenuated one, have shown promise. The combination vaccine in its present state of development confers only a transient protection in young children, while the live attenuated one produces adverse reaction. To combat these, various strategies are being evolved. In one attempt, a potential candidate vaccine strain has been constructed from a non-reactogenic clinical isolate of V. cholerae, which is devoid of all known major virulence genes and is also a good colonizer. In animal studies this construct has shown considerable promise. This review discusses the various strategies that have been employed so far in the quest for an ideal cholera vaccine.

Item Type: Article
Additional Information: Copyright of this article belongs to ICMR, New Delhi
Subjects: R Medicine > R Medicine (General)
Depositing User: Dr. K.P.S.Sengar
Date Deposited: 13 Dec 2011 16:45
Last Modified: 13 Dec 2011 16:45

Actions (login required)

View Item View Item