Biotransformations of rifamycins: process possibilities.

Banerjee, U C and Saxena, B and Chisti, Y. (1992) Biotransformations of rifamycins: process possibilities. Biotechnology advances, 10 (4). pp. 577-95. ISSN 0734-9750

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Rifampicin, an important antibiotic, is manufactured by chemical conversion of rifamycin S which is obtained by the chemical modification of rifamycin B. Rifamycin B is a product of Nocardia mediterranei fermentations. The chemical conversion of rifamycin B to rifamycin S has many disadvantages: Strong acidic conditions are required, heavy foam formation accompanies transformation and the yields are low. This review highlights the developments in alternative, biochemical transformations using enzymes and cells; the main focus is on transformations carried out by rifamycin oxidase.

Item Type: Article
Additional Information: Copyright of this article belongs to Elsevier Science
Subjects: Q Science > QD Chemistry
Depositing User: Dr. K.P.S.Sengar
Date Deposited: 12 Dec 2011 15:38
Last Modified: 29 Mar 2012 06:48

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