Computer-aided biotechnology: from immuno-informatics to reverse vaccinology.

Vivona, Sandro and Gardy, Jennifer L and Ramachandran, Srinivasan and Brinkman, Fiona S L and Raghava, G.P.S. and Flower, Darren R and Filippini, Francesco (2008) Computer-aided biotechnology: from immuno-informatics to reverse vaccinology. Trends in biotechnology, 26 (4). pp. 190-200. ISSN 0167-7799

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Genome sequences from many organisms, including humans, have been completed, and high-throughput analyses have produced burgeoning volumes of 'omics' data. Bioinformatics is crucial for the management and analysis of such data and is increasingly used to accelerate progress in a wide variety of large-scale and object-specific functional analyses. Refined algorithms enable biotechnologists to follow 'computer-aided strategies' based on experiments driven by high-confidence predictions. In order to address compound problems, current efforts in immuno-informatics and reverse vaccinology are aimed at developing and tuning integrative approaches and user-friendly, automated bioinformatics environments. This will herald a move to 'computer-aided biotechnology': smart projects in which time-consuming and expensive large-scale experimental approaches are progressively replaced by prediction-driven investigations.

Item Type: Article
Additional Information: Copyright of this articlebelongs to Elsevier Science.
Subjects: Q Science > QR Microbiology
Depositing User: Dr. K.P.S.Sengar
Date Deposited: 10 Jan 2012 08:05
Last Modified: 10 Jan 2012 08:05

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