Receptor-mediated drug delivery to macrophages in chemotherapy of leishmaniasis.

Mukhopadhyay, A and Chaudhuri, G and Arora, S K and Sehgal, S and Basu, S K (1989) Receptor-mediated drug delivery to macrophages in chemotherapy of leishmaniasis. Science (New York, N.Y.), 244 (4905). pp. 705-7. ISSN 0036-8075

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Abstract

Methotrexate coupled to maleylated bovine serum albumin was taken up efficiently through the "scavenger" receptors present on macrophages and led to selective killing of intracellular Leishmania mexicana amazonensis amastigotes in cultured hamster peritoneal macrophages. The drug conjugate was nearly 100 times as effective as free methotrexate in eliminating the intracellular parasites. Furthermore, in a model of experimental cutaneous leishmaniasis in hamsters, the drug conjugate brought about more than 90% reduction in the size of footpad lesions within 11 days. In contrast, the free drug at a similar concentration did not significantly affect lesion size. These studies demonstrate the potential of receptor-mediated drug delivery in the therapy of macrophage-associated diseases.

Item Type:	Article
Additional Information:	Copyright of this article belongs to AAAS
Subjects:	Q Science > Q Science (General)
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	12 Dec 2011 15:41
Last Modified:	12 Dec 2011 15:41
URI:	http://crdd.osdd.net/open/id/eprint/436

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