Raghava, G.P.S. and Barton, Geoffrey J (2006) Quantification of the variation in percentage identity for protein sequence alignments. BMC bioinformatics, 7. p. 415. ISSN 1471-2105
|
PDF (OPEN ACCESS)
raghava2006.4.pdf - Published Version Available under License Creative Commons Attribution. Download (206Kb) | Preview |
Abstract
Although it is well known amongst expert sequence analysts that PID is a poor score for discriminating between protein sequences, the apparent simplicity of the percentage identity score encourages its widespread use in establishing cutoffs for structural similarity. This paper illustrates that not only is PID a poor measure of sequence similarity when compared to the Z-score, but that there is also a large uncertainty in reported PID values. Since better alternatives to PID exist to quantify sequence similarity, these should be quoted where possible in preference to PID. The findings presented here should prove helpful to those new to sequence analysis, and in warning those who seek to interpret the value of a PID reported in the literature.
| Item Type: | Article |
|---|---|
| Additional Information: | OPEN ACCESS |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 10 Jan 2012 08:06 |
| Last Modified: | 10 Jan 2012 08:06 |
| URI: | http://crdd.osdd.net/open/id/eprint/67 |
Actions (login required)
 |
View Item |
