Bhui, AJ and Bureau, J and Abbas, A and Mondal, A (1996) Novel cellular markers in breast cancer: Differential presence of p23K and p30.33K prosomal antigens in tumors of Parsi and non-Parsi women. INTERNATIONAL JOURNAL OF ONCOLOGY, 9 (4). pp. 669-677. ISSN 1019-6439
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Epidemiological studies have revealed that Parsi women have a higher incidence of breast cancer than non-Parsis and that they are more susceptible to breast cancer. We have studied the cellular distribution of two prosomal proteins p23K in parallel to the p30.33K and proliferation marker Ki-67 as potential markers to identify high risk population for breast cancers. Flow cytometry data demonstrated that the Parsi benign and non-Parsi malignants have a higher number of cells labelled with these two prosomal protein antibodies than the non-Parsi benign and European 'normals'. Using immunohistochemical methods, p23 K was found to be significantly higher in Parsi and non-Parsi malignants as well as in non-Parsi benigns. In our FCM analysis, intergroup comparison showed, interestingly, a significantly higher expression of both p23K and p30.33K in Parsi benigns as compared to non-Parsis, raising the possibility that benign tumors of Parsis represent already premalignant lesions. The present study, in addition, proposes the prosomal antigens as likely cell proliferation markers comparable to Ki-67.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to PROFESSOR D A SPANDIDOS, EDITORIAL OFFICE, 1, S MERKOURI ST, ATHENS 116 35, GREECE. |
| Subjects: | R Medicine > RZ Other systems of medicine |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 27 Jan 2012 15:07 |
| Last Modified: | 29 Mar 2012 06:22 |
| URI: | http://crdd.osdd.net/open/id/eprint/751 |
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