Spectral analysis of the effect of inflow noise on a fed-batch fermentation for recombinant β-galactosidase

Patnaik, P R (1997) Spectral analysis of the effect of inflow noise on a fed-batch fermentation for recombinant β-galactosidase. Bioprocess Engineering, 17 (2). p. 93. ISSN 0178515X

PDF patnaik1997.pdf - Published Version Restricted to Registered users only Download (189Kb) | Request a copy

Abstract

The fermentative production of β-galactosidase from Escherichia coli CSH50 containing the plasmid pOU140 is mechanistically complex and difficult to model in a nonideal bioreactor. A spectral analysis has been done for a fed-batch fermentation with Gaussian disturbances in the feed stream. Inflow noise converts a smooth operation into aperiodic motion, as observed in some chemical reactions also. The disturbances also cause significant differences in the frequency responses of intra-cellular (plasmid DNA and β-galactosidase) and extra-cellular (concentration and mass fraction of recombinant cells) variables, whose implications are discussed.

Item Type:	Article
Additional Information:	Copyright of this article belongs to Springer Science.
Subjects:	Q Science > QR Microbiology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	27 Jan 2012 15:04
Last Modified:	12 Jan 2015 04:13
URI:	http://crdd.osdd.net/open/id/eprint/763

Actions (login required)

View Item