Agrewala, J N and Suvas, S and Joshi, A and Bhatnagar, A. and Vinay, D S and Mishra, G C (1998) M150 modulates the costimulatory signals delivered by B cells to T cells and enhances their ability to help B cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 18 (5). pp. 297-304. ISSN 1079-9907
Full text not available from this repository. (Request a copy)Abstract
There is a prerequirement of at least two sets of signals delivered by the antigen-presenting cell (APC) for the optimal activation of T helper (Th) cells. The first signal is provided by the engagement of T cell receptor with the antigen-MHC class II complex, followed by a second stimulus in the form of costimulatory signals. In the present study, we provide evidence that in a T-dependent antigen-driven system, the signals generated by hapten-specific B cells to stimulate Th cells for the secretion of interleukin-2 (IL-2), interferon-gamma (IFN-gamma), and IL-4 were differentially modified by M150, a 150-kDa molecule expressed on the surface of macrophages. When ovalbumin-specific Th cells were cultured in the presence of 2,4,6 trinitrophenol (TNP)-specific B cells, M150 significantly increased the proliferation of Th cells and the secretion of IL-2 and IFN-gamma and decreased the production of IL-4. Further, Th cells stimulated with M150 acquired improved ability to help B cells, resulting in an increase in the number of antibody-secreting cells and in the production of TNP-specific IgG2a antibodies. M150 possibly promotes Th1-like cell activity, as evidenced by predominant secretion of IL-2, IFN-gamma, and IgG2a but not IL-4 and IgG1.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to Mary Ann Liebert. |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 30 Jan 2012 17:58 |
| Last Modified: | 29 Mar 2012 06:21 |
| URI: | http://crdd.osdd.net/open/id/eprint/780 |
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