Apoptosis of Th1-like cells in experimental tuberculosis (TB)

Das, G and Vohra, H and Saha, B and Agrewala, J N and Mishra, G C (1999) Apoptosis of Th1-like cells in experimental tuberculosis (TB). Clinical and Experimental Immunology, 115 (2). pp. 324-328. ISSN 0009-9104

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Abstract

Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bcl-2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon-gamma (IFN-γ) but not of IL-4. These changes may result in selective apoptosis of Th1-like cells, leading to the loss of cell-mediated immune response against M. tuberculosis.

Item Type:	Article
Additional Information:	Copyright of this article belongs to Wiley.
Uncontrolled Keywords:	apoptosis, tuberculosis, Th1 cells, Fas, Bcl-2
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	30 Jan 2012 17:55
Last Modified:	09 Jan 2015 11:17
URI:	http://crdd.osdd.net/open/id/eprint/797

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