Transient sensitivity analysis of a cybernetic model of microbial growth on two substrates

Patnaik, P R (1999) Transient sensitivity analysis of a cybernetic model of microbial growth on two substrates. Bioprocess Engineering, 21 (2). p. 135. ISSN 0178515X

PDF patnaik1999.3.pdf - Published Version Restricted to Registered users only Download (453Kb) | Request a copy

Abstract

When a microbe has a choice of two substrates for its growth in a fermentation medium, its preference varies with the substrates and with time. This "informed" choice is conveniently expressed by cybernetic models. For the growth of Klebsiella oxytoca in a medium of glucose and lactose, a one-parameter cybernetic model of growth has been employed in a batch bioreactor to analyse sensitivity of the fermentation to perturbations in the parameter, ! (0 h ! h 1). The sensitivity surfaces in the (!-time) space show interesting variations which are discussed. An important observation is that while growth is best promoted with !=1, i.e. sequential consumption of the substrates [8], low sensitivities require smaller values of !, i.e. simultaneous utilisation. Thus, in a realistic operation it may be necessary to compromise between high growth (with subsequent high productivity) and low sensitivity.

Item Type:	Article
Additional Information:	Copyright of this article belongs to Sprinegr science.
Subjects:	Q Science > QR Microbiology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	31 Jan 2012 08:44
Last Modified:	12 Jan 2015 04:11
URI:	http://crdd.osdd.net/open/id/eprint/808

Actions (login required)

View Item