Accelerated proteasomal degradation of membrane Ig heavy chains.

Ho, S C and Chaudhuri, Saumya Ray and Bachhawat, Anand K and McDonald, K and Pillai, S (2000) Accelerated proteasomal degradation of membrane Ig heavy chains. Journal of immunology (Baltimore, Md. : 1950), 164 (9). pp. 4713-9. ISSN 0022-1767

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Abstract

Membrane IgG H chains turn over considerably more rapidly than secretory Ig H chains in the 18-81 A2 pre-B cell line. This rapid degradation occurs in proteasomes. N-Glycosylated membrane Ig H chains accumulate in the endoplasmic reticulum in the presence of proteasomal inhibitors, suggesting that retrotranslocation and proteasomal degradation of membrane Ig H chains may be closely coupled processes. Accelerated proteasomal degradation of membrane Ig H chains was also observed in transfected nonlymphoid cells. At steady state, the membrane form of the H chain associates more readily with Bip and calnexin than its secretory counterpart. The preferential recognition of membrane, as opposed to secretory, Ig H chains by some endoplasmic reticulum chaperones, may provide an explanation for the accelerated proteasomal degradation of the former.

Item Type:	Article
Additional Information:	Copyright of this article belongs to American Association of Immunologists.
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	02 Feb 2012 05:03
Last Modified:	07 Jan 2015 09:08
URI:	http://crdd.osdd.net/open/id/eprint/833

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