Singh, S. and Khatri, Neeraj and Manuja, A. and Sharma, R.D. and Malhotra, D.V. and Nichani, A.K. (2001) Impact of field vaccination with a Theileria annulata schizont cell culture vaccine on the epidemiology of tropical theileriosis. Veterinary Parasitology, 101 (2). pp. 91-100. ISSN 03044017
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Abstract
Tropical theileriosis, caused by Theileria annulata, is an important tick-borne disease of cattle. A cell culture attenuated vaccine has been developed in our laboratory by long-term in vitro propagation of the schizont stage of the parasite. A longitudinal study was conducted at selected farms housing indigenous, cross-bred and exotic animals to investigate the effect of vaccination on the epidemiology of the disease. A total of 120 animals in 4 age groups were vaccinated with the vaccine before the onset of disease season. An equal number of age-matched animals were kept as controls at the same sites. Animals were monitored for 14 months at monthly intervals. The 97.5% vaccinated animals showed a rise in antibody titres 1 month post-vaccination, as determined by single dilution ELISA. The 78.3% of non-vaccinated animals became sero-positive over the period of observation. Mean antibody titres were significantly higher in vaccinated than non-vaccinated animals. Cross-bred animals showed higher antibody titres followed by exotic and indigenous animals in both the vaccinated and non-vaccinated groups. However, the antibody titres in animals of different ages were similar. The 36.7% vaccinated and 64.2% non-vaccinated animals became carriers (<0.5% piroplasms in erythrocytes) during the observation period. Clinical cases of theileriosis were recorded only in the non-vaccinated group suggesting that vaccinated animals were sufficiently immune to withstand field tick challenge for at least 14 months.
Item Type: | Article |
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Additional Information: | Copyright of this article belongs to Elsevier Science. |
Uncontrolled Keywords: | Theileria annulata; Field vaccination; Epidemiology |
Subjects: | R Medicine > RZ Other systems of medicine |
Depositing User: | Dr. K.P.S.Sengar |
Date Deposited: | 03 Feb 2012 05:51 |
Last Modified: | 22 Jul 2015 05:17 |
URI: | http://crdd.osdd.net/open/id/eprint/856 |
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