TY  - JOUR
ID  - open1013
UR  - http://www.sciencedirect.com/science/article/pii/S0014299906002354
IS  - 3
A1  - Sharma, Sameer
A1  - Kulkarni, S K
A1  - Agrewala, J N
A1  - Chopra, Kanwaljit
N2  - Diabetic neuropathic pain, an important microvascular complication in diabetes mellitus is recognised as one of the most difficult types of pain to treat. A lack of the understanding of its aetiology, inadequate relief, development of tolerance and potential toxicity of classical antinociceptives warrant the investigation of the newer agents to relieve this pain. The aim of the present study was to explore the antinociceptive effect of curcumin and its effect on tumour necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) release in streptozotocin induced diabetic mice. Four weeks after a single intraperitoneal injection of streptozotocin (200 mg/kg), mice were tested in the tail immersion and hot-plate assays. Diabetic mice exhibited significant hyperalgesia along with increased plasma glucose and decreased body weights as compared with control mice. Chronic treatment with curcumin (15, 30 and 60 mg/kg body weight; p.o.) for 4 weeks starting from the 4th week of streptozotocin injection significantly attenuated thermal hyperalgesia and the hot-plate latencies. Curcumin also inhibited the TNF-alpha and NO release in a dose dependent manner. These results indicate an antinociceptive activity of curcumin possibly through its inhibitory action on NO and TNF-alpha release and point towards its potential to attenuate diabetic neuropathic pain.
VL  - 536
TI  - Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain.
AV  - restricted
EP  - 61
N1  - Copyright of this article belongs to Elsevier Science.
Y1  - 2006/05/01/
PB  - Elsevier Science
JF  - European journal of pharmacology
KW  - Diabetic neuropathic pain; Hyperalgesia; Curcumin; Nitric oxide; TNF-?; Streptozotocin
SN  - 0014-2999
SP  - 256
ER  -