<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity."^^ . "EBV is associated with systemic lupus erythematosus (SLE), but how it might contribute to the etiology is not clear. Since EBV-encoded latent membrane protein 2A (LMP2A) interferes with normal B cell differentiation and function, we sought to determine its effect on B cell tolerance. Mice transgenic for both LMP2A and the Ig transgene 2-12H specific for the ribonucleoprotein Smith (Sm), a target of the immune system in SLE, develop a spontaneous anti-Sm response. LMP2A allows anti-Sm B cells to overcome the regulatory checkpoint at the early preplasma cell stage by a self-Ag-dependent mechanism. LMP2A induces a heightened sensitivity to TLR ligand stimulation, resulting in increased proliferation or Ab-secreting cell differentiation or both. Thus, we propose a model whereby LMP2A induces hypersensitivity to TLR stimulation, leading to activation of anti-Sm B cells through the BCR/TLR pathway. These data further implicate TLRs in the etiology of SLE and suggest a mechanistic link between EBV infection and SLE."^^ . "2006-09-01" . . "177" . "5" . . "American Association of Immunologists"^^ . . . "Journal of immunology (Baltimore, Md. : 1950)"^^ . . . "00221767" . . . . . . . . . . . . . . . . . . . . . . . . . "Stephen H"^^ . "Clarke"^^ . "Stephen H Clarke"^^ . . "Pradip"^^ . "Sen"^^ . "Pradip Sen"^^ . . "Hongsheng"^^ . "Wang"^^ . "Hongsheng Wang"^^ . . "Ramiro"^^ . "Diz"^^ . "Ramiro Diz"^^ . . "Roland M"^^ . "Tisch"^^ . "Roland M Tisch"^^ . . "Kara L"^^ . "Conway"^^ . "Kara L Conway"^^ . . "Matilda W"^^ . "Nicholas"^^ . "Matilda W Nicholas"^^ . . . . . . "EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity. (PDF)"^^ . . . . . "EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity. (Indexer Terms)"^^ . . . . . . "EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity. (Image (PNG))"^^ . . . . . . "EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity. (Image (PNG))"^^ . . . . . . "EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity. (Image (PNG))"^^ . . . . . . "EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity. (Image (PNG))"^^ . . . . . "HTML Summary of #1026 \n\nEBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity.\n\n" . "text/html" . . . "QR180 Immunology"@en . .