%A N Bachhawat
%A Balvinder Singh
%O Copyright of this article belongs to Science Press.
%J Genomics, proteomics & bioinformatics / Beijing Genomics Institute
%T Mycobacterial PE_PGRS proteins contain calcium-binding motifs with parallel beta-roll folds.
%X The PE_PGRS family of proteins unique to mycobacteria is demonstrated to contain multiple calcium-binding and glycine-rich sequence motifs GGXGXD/NXUX. This sequence repeat constitutes a calcium-binding parallel beta-roll or parallel beta-helix structure and is found in RTX toxins secreted by many Gram-negative bacteria. It is predicted that the highly homologous PE PGRS proteins containing multiple copies of the nona-peptide motif could fold into similar calcium-binding structures. The implication of the predicted calcium-binding property of PE PGRS proteins in the light of macrophage-pathogen interaction and pathogenesis is presented.
%N 3-4
%P 236-41
%V 5
%D 2007
%I Science Press
%L open1036