TY  - JOUR
ID  - open1053
UR  - http://dx.doi.org/10.1080/00986440600992677
IS  - 5
A1  - Patnaik, P R
N2  - Unlike laboratory-scale bioreactors, large reactors have finite dispersion and are affected by unexpected interruptions in the feed streams. For the optimum level of dispersion determined earlier, the effects of interruptions in the inflow of the carbon (glucose) and nitrogen (NH4Cl) substrates have been studied for fed-batch fermentation by Ralstonia eutropha to produce poly-?-hydroxybutyrate (PHB). Optimum uninterrupted operation by neural control at dispersion corresponding to Pe = 20 was used as the reference. While glucose stoppage mainly affected cell growth, nitrogen flow suppressed polymer synthesis more strongly. The effects depended also on the time at which the interruptions occurred. These results are interpreted in a metabolic context, emphasizing the complexity of the system and the importance of ?intelligent? monitoring and control under disturbed conditions
VL  - 194
TI  - ANALYSIS OF THE EFFECT OF FLOW INTERRUPTIONS ON FED-BATCH FERMENTATION FOR PHB PRODUCTION BYRALSTONIA EUTROPHAIN FINITELY DISPERSED BIOREACTORS
AV  - none
EP  - 617
N1  - Copyright of this article belongs to Taylor and Francis.
Y1  - 2007///
PB  - Taylor and francis group
JF  - Chemical Engineering Communications
KW  - Fed-batch fermentation
KW  -  Flow interruptions
KW  -  Optimum dispersion
KW  -  Poly-?-hydroxybutyrate
SN  - 0098-6445
SP  - 603
ER  -