<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Unique Ability of Activated CD4+ T Cells but Not Rested Effectors to Migrate to Non-lymphoid Sites in the Absence of Inflammation"^^ . "Recent studies suggest that effector T cells generated by\r\nimmune responses migrate to multiple non-lymphoid sites,\r\neven those without apparent expression of antigen or inflammation.\r\nTo investigate the ability of distinct CD4� T lymphocyte\r\nsubsets to enter and persist in non-lymphoid, noninflamed\r\ncompartments, we examined the migration and\r\npersistence of naı¨ve, effector, and rested effector CD4� T\r\ncells generated in vitro following transfer to nonimmunized\r\nadoptive hosts. Th1 and Th2 effectors migrated to both\r\nlymphoid and non-lymphoid organs (peritoneum, fat pads,\r\nand lung). In contrast, rested effectors and naı¨ve cells\r\nmigrated only to lymphoid areas. Adhesion molecule expression,\r\nbut not chemokine receptor expression, correlated with\r\nthe ability to enter non-lymphoid sites. Donor cells persisted\r\nlonger in lymphoid than in non-lymphoid sites. When hosts\r\nwith naı¨ve and memory donor cells were challenged with\r\nantigen, effectors developed in situ, which also migrated to\r\nnon-lymphoid sites. Memory cells showed an accelerated\r\nshift to non-lymphoid migration, in keeping with memory\r\neffector formation. These results suggest that only recently\r\nactivated effector T cells can disperse to non-lymphoid sites in the absence of antigen and inflammation, and as effectors return to rest, they lose this ability. These data also argue that memory cells in lymphoid sites are longer lived and not in equilibrium with those in non-lymphoid sites."^^ . "2007" . . "282" . . "ASBMB"^^ . . . "Journal of Biological Chemistry"^^ . . . "00219258" . . . . . . . . . . . . . . . . . . . . . . "J N"^^ . "Agrewala"^^ . "J N Agrewala"^^ . . "M.M."^^ . "Lepak"^^ . "M.M. Lepak"^^ . . "S.L."^^ . "Swain"^^ . "S.L. Swain"^^ . . "Gail"^^ . "Huston"^^ . "Gail Huston"^^ . . "D."^^ . "Duso"^^ . "D. Duso"^^ . . "Deborah M"^^ . "Brown"^^ . "Deborah M Brown"^^ . . . . . . "Unique Ability of Activated CD4+ T Cells but Not Rested Effectors to Migrate to Non-lymphoid Sites in the Absence of Inflammation (PDF)"^^ . . . . . "Unique Ability of Activated CD4+ T Cells but Not Rested Effectors to Migrate to Non-lymphoid Sites in the Absence of Inflammation (Indexer Terms)"^^ . . . . . . "Unique Ability of Activated CD4+ T Cells but Not Rested Effectors to Migrate to Non-lymphoid Sites in the Absence of Inflammation (Image (PNG))"^^ . . . . . . "Unique Ability of Activated CD4+ T Cells but Not Rested Effectors to Migrate to Non-lymphoid Sites in the Absence of Inflammation (Image (PNG))"^^ . . . . . . "Unique Ability of Activated CD4+ T Cells but Not Rested Effectors to Migrate to Non-lymphoid Sites in the Absence of Inflammation (Image (PNG))"^^ . . . . . . "Unique Ability of Activated CD4+ T Cells but Not Rested Effectors to Migrate to Non-lymphoid Sites in the Absence of Inflammation (Image (PNG))"^^ . . . . . "HTML Summary of #1056 \n\nUnique Ability of Activated CD4+ T Cells but Not Rested Effectors to Migrate to Non-lymphoid Sites in the Absence of Inflammation\n\n" . "text/html" . . . "QD Chemistry"@en . .