@article{open1057,
          volume = {15},
          number = {3},
           month = {March},
          author = {Saumya Ray Chaudhuri and Joshua N Mallam and Patricia Ch{\'e}vez-Barrios and Lalita Wadhwa and Philip Ng and Mary Y Hurwitz and Richard L Hurwitz},
            note = {Copyright of this article belongs to Nature Publishing Group.},
           title = {Modulation of adenoviral transduction in vitro and in vivo by hyaluronan and its receptor CD44.},
       publisher = {Nature Publishing Group},
            year = {2007},
         journal = {Molecular therapy : the journal of the American Society of Gene Therapy},
           pages = {566--70},
             url = {http://crdd.osdd.net/open/1057/},
        abstract = {Adenovirus infection is a significant cause of ocular, respiratory, and gastrointestinal illness and can spread rapidly. Morbidity is considerable in immune-suppressed individuals and there is significant mortality. There are no effective therapies. During preclinical studies of adenoviral-mediated gene therapy for ocular disorders, we noticed a significant increase in transduction when the target cells were exposed to adenovirus in the presence of ocular vitreous. The vitreous is mainly comprised of water, collagen, and the large polysaccharide hyaluronan. In this paper, we report data that implicate hyaluronan in the adenoviral infectious process and show that interference with the interaction between hyaluronan and its cellular receptor CD44 can block adenovirus transduction in vitro and in vivo.}
}