creators_name: Chaudhuri, Saumya Ray
creators_name: Mallam, Joshua N
creators_name: Chévez-Barrios, Patricia
creators_name: Wadhwa, Lalita
creators_name: Ng, Philip
creators_name: Hurwitz, Mary Y
creators_name: Hurwitz, Richard L
type: article
datestamp: 2012-02-17 16:38:21
lastmod: 2012-03-29 07:26:59
metadata_visibility: show
title: Modulation of adenoviral transduction in vitro and in vivo by hyaluronan and its receptor CD44.
ispublished: pub
subjects: R1
full_text_status: restricted
note: Copyright of this article belongs to Nature Publishing Group.
abstract: Adenovirus infection is a significant cause of ocular, respiratory, and gastrointestinal illness and can spread rapidly. Morbidity is considerable in immune-suppressed individuals and there is significant mortality. There are no effective therapies. During preclinical studies of adenoviral-mediated gene therapy for ocular disorders, we noticed a significant increase in transduction when the target cells were exposed to adenovirus in the presence of ocular vitreous. The vitreous is mainly comprised of water, collagen, and the large polysaccharide hyaluronan. In this paper, we report data that implicate hyaluronan in the adenoviral infectious process and show that interference with the interaction between hyaluronan and its cellular receptor CD44 can block adenovirus transduction in vitro and in vivo.
date: 2007-03
date_type: published
publication: Molecular therapy : the journal of the American Society of Gene Therapy
volume: 15
number: 3
publisher: Nature Publishing Group
pagerange: 566-70
refereed: TRUE
issn: 1525-0024
official_url: http://www.nature.com/mt/journal/v15/n3/pdf/6300044a.pdf
related_url_url: http://www.nature.com/mt/journal/v15/n3/pdf/6300044a.pdf
related_url_type: pub
citation:   Chaudhuri, Saumya Ray and Mallam, Joshua N and Chévez-Barrios, Patricia and Wadhwa, Lalita and Ng, Philip and Hurwitz, Mary Y and Hurwitz, Richard L  (2007) Modulation of adenoviral transduction in vitro and in vivo by hyaluronan and its receptor CD44.  Molecular therapy : the journal of the American Society of Gene Therapy, 15 (3).  pp. 566-70.  ISSN 1525-0024     
document_url: http://crdd.osdd.net/open/1057/1/saumya2007.pdf