%0 Journal Article
%@ 1517-8382
%A Kalia, S.B.
%A Kaushal, G.
%A Kumar(1), Manoj
%A Cameotra, Swaranjit Singh
%A Sharma, A.
%A Verma , M.L.
%A Kanwar, S.S.
%D 2009
%F open:1089
%I Sociedade Brasileira de Microbiologia - SBM 
%J Brazilian Journal of Microbiology
%K antimicrobial, metal ions, 4-methylpiperazine-1-carbodithioate, MIC, zone of inhibition
%P 916-922
%T Antimicrobial and toxicological studies of some metal complexes of 4- methylpiperazine-1-carbodithioate and phenanthroline mixed ligands
%U http://crdd.osdd.net/open/1089/
%V 40
%X A few mixed ligand transition metal carbodithioate complexes of the general formula [M(4-  MPipzcdt)x(phen)y]Y (M = Mn(II), Co(II), Zn(II); 4-MPipzcdt = 4-methylpiperazine-1-carbodithioate;  phen = 1,10-phenanthroline; x = 1 and y = 2 when Y = Cl; x = 2 and y = 1 when Y = nil) were synthesized  and screened for their antimicrobial activity against Candida albicans, Escherichia coli, Pseudomonas  aeruginosa, Staphylococcus aureus and Enterococcus faecalis by disk diffusion method. All the  complexes exhibited prominent antimicrobial activity against tested pathogenic strains with the MIC  values in the range <8-512 �gmL-1. The complexes [Mn(4-MPipzcdt)2(phen)] and [Co(4-  MPipzcdt)(phen)2]Cl inhibited the growth of Candida albicans at a concentration as low as 8 μgmL-1. The  complexes were also evaluated for their toxicity towards human transformed rhabdomyosarcoma cells  (RD cells). Moderate cell viability of the RD cells was exhibited against the metal complexes.