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primary topic: Antimicrobial and toxicological studies of some metal complexes of 4- methylpiperazine-1-carbodithioate and phenanthroline mixed ligands

Antimicrobial and toxicological studies of some metal complexes of 4- methylpiperazine-1-carbodithioate and phenanthroline mixed ligands
type: AcademicArticle
type: Article
abstract: A few mixed ligand transition metal carbodithioate complexes of the general formula [M(4- MPipzcdt)x(phen)y]Y (M = Mn(II), Co(II), Zn(II); 4-MPipzcdt = 4-methylpiperazine-1-carbodithioate; phen = 1,10-phenanthroline; x = 1 and y = 2 when Y = Cl; x = 2 and y = 1 when Y = nil) were synthesized and screened for their antimicrobial activity against Candida albicans, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus faecalis by disk diffusion method. All the complexes exhibited prominent antimicrobial activity against tested pathogenic strains with the MIC values in the range <8-512 �gmL-1. The complexes [Mn(4-MPipzcdt)2(phen)] and [Co(4- MPipzcdt)(phen)2]Cl inhibited the growth of Candida albicans at a concentration as low as 8 μgmL-1. The complexes were also evaluated for their toxicity towards human transformed rhabdomyosarcoma cells (RD cells). Moderate cell viability of the RD cells was exhibited against the metal complexes.
date: 2009
volume: 40
is part of: Brazilian Journal of Microbiology
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
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subject: QR Microbiology

Antimicrobial and toxicological studies of some metal complexes of 4- methylpiperazine-1-carbodithioate and phenanthroline mixed ligands (PDF)
type: Document
has file: swaranjit2009.pdf
has part: swaranjit2009.pdf

Sociedade Brasileira de Microbiologia - SBM
type: Organization

Brazilian Journal of Microbiology
type: Collection
issn: 15178382

A. Sharma
type: Person
given name: A.
family name: Sharma

S.S. Kanwar
type: Person
given name: S.S.
family name: Kanwar

Manoj Kumar(1)
type: Person
given name: Manoj
family name: Kumar(1)

G. Kaushal
type: Person
given name: G.
family name: Kaushal

Swaranjit Singh Cameotra
type: Person
given name: Swaranjit Singh
family name: Cameotra

S.B. Kalia
type: Person
given name: S.B.
family name: Kalia

M.L. Verma
type: Person
given name: M.L.
family name: Verma

Antimicrobial and toxicological studies of some metal complexes of 4- methylpiperazine-1-carbodithioate and phenanthroline mixed ligands (Indexer Terms)
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primary topic: Antimicrobial and toxicological studies of some metal complexes of 4- methylpiperazine-1-carbodithioate and phenanthroline mixed ligands

QR Microbiology
type: Concept