%A S.B. Kalia
%A G. Kaushal
%A Manoj Kumar(1)
%A Swaranjit Singh Cameotra
%A A. Sharma
%A M.L. Verma 
%A S.S. Kanwar
%J Brazilian Journal of Microbiology
%T Antimicrobial and toxicological studies of some metal complexes of 4- methylpiperazine-1-carbodithioate and phenanthroline mixed ligands
%X A few mixed ligand transition metal carbodithioate complexes of the general formula [M(4-
MPipzcdt)x(phen)y]Y (M = Mn(II), Co(II), Zn(II); 4-MPipzcdt = 4-methylpiperazine-1-carbodithioate;
phen = 1,10-phenanthroline; x = 1 and y = 2 when Y = Cl; x = 2 and y = 1 when Y = nil) were synthesized
and screened for their antimicrobial activity against Candida albicans, Escherichia coli, Pseudomonas
aeruginosa, Staphylococcus aureus and Enterococcus faecalis by disk diffusion method. All the
complexes exhibited prominent antimicrobial activity against tested pathogenic strains with the MIC
values in the range <8-512 ?gmL-1. The complexes [Mn(4-MPipzcdt)2(phen)] and [Co(4-
MPipzcdt)(phen)2]Cl inhibited the growth of Candida albicans at a concentration as low as 8 ?gmL-1. The
complexes were also evaluated for their toxicity towards human transformed rhabdomyosarcoma cells
(RD cells). Moderate cell viability of the RD cells was exhibited against the metal complexes.
%K antimicrobial, metal ions, 4-methylpiperazine-1-carbodithioate, MIC, zone of inhibition
%P 916-922
%V 40
%D 2009
%I Sociedade Brasileira de Microbiologia - SBM 
%L open1089