creators_name: Kalia, S.B.
creators_name: Kaushal, G.
creators_name: Kumar(1), Manoj
creators_name: Cameotra, Swaranjit Singh
creators_name: Sharma, A.
creators_name: Verma , M.L.
creators_name: Kanwar, S.S.
type: article
datestamp: 2012-02-28 16:11:30
lastmod: 2016-03-01 06:28:28
metadata_visibility: show
title: Antimicrobial and toxicological studies of some metal complexes of 4- methylpiperazine-1-carbodithioate and phenanthroline mixed ligands
ispublished: pub
subjects: QR
full_text_status: public
keywords: antimicrobial, metal ions, 4-methylpiperazine-1-carbodithioate, MIC, zone of inhibition
abstract: A few mixed ligand transition metal carbodithioate complexes of the general formula [M(4-
MPipzcdt)x(phen)y]Y (M = Mn(II), Co(II), Zn(II); 4-MPipzcdt = 4-methylpiperazine-1-carbodithioate;
phen = 1,10-phenanthroline; x = 1 and y = 2 when Y = Cl; x = 2 and y = 1 when Y = nil) were synthesized
and screened for their antimicrobial activity against Candida albicans, Escherichia coli, Pseudomonas
aeruginosa, Staphylococcus aureus and Enterococcus faecalis by disk diffusion method. All the
complexes exhibited prominent antimicrobial activity against tested pathogenic strains with the MIC
values in the range <8-512 �gmL-1. The complexes [Mn(4-MPipzcdt)2(phen)] and [Co(4-
MPipzcdt)(phen)2]Cl inhibited the growth of Candida albicans at a concentration as low as 8 μgmL-1. The
complexes were also evaluated for their toxicity towards human transformed rhabdomyosarcoma cells
(RD cells). Moderate cell viability of the RD cells was exhibited against the metal complexes.
date: 2009
date_type: published
publication: Brazilian Journal of Microbiology
volume: 40
publisher: Sociedade Brasileira de Microbiologia - SBM 
pagerange: 916-922
refereed: TRUE
issn: 1517-8382
official_url: http://www.scielo.br/pdf/bjm/v40n4/v40n4a24.pdf
related_url_url: http://www.scielo.br/pdf/bjm/v40n4/v40n4a24.pdf
related_url_type: pub
citation:   Kalia, S.B. and Kaushal, G. and Kumar(1), Manoj and Cameotra, Swaranjit Singh and Sharma, A. and Verma , M.L. and Kanwar, S.S.  (2009) Antimicrobial and toxicological studies of some metal complexes of 4- methylpiperazine-1-carbodithioate and phenanthroline mixed ligands.  Brazilian Journal of Microbiology, 40.  pp. 916-922.  ISSN 1517-8382     
document_url: http://crdd.osdd.net/open/1089/1/swaranjit2009.pdf