creators_name: Patnaik, Pratap R
type: article
datestamp: 2012-02-28 16:10:16
lastmod: 2012-02-28 16:10:16
metadata_visibility: show
title: Transient response analysis of the eukaryotic chemosensory system to intra-cellular fluctuations.
ispublished: pub
subjects: QR
full_text_status: none
keywords: Eukaryotic cells; chemosensory system; intra-cellular noise; transient response
note: Copyright of this article belongs to World Scientific Publishing.


abstract: Like prokaryotic cells, those of eukaryotes are also subjected to noise from within the cells. While the cells have a built-in mechanism to attenuate the noise, conditions may arise where this is beyond the cell's ability to regulate. Start-up perturbations and those induced by metabolic shifts are examples of such situations. Then, it becomes useful to understand how the cells respond. For a eukaryotic chemosensory system, this has been studied by applying response coefficient analysis to a recent model. With even three dependent variables - an activator, an inhibitor, and a response element - the response coefficients differ widely with time and from one variable to another. These differences are interpreted in terms of the chemosensory mechanism and its robustness. The results complement similar recent studies of Escherichia coli chemotaxis, thus supporting their credibility and versatility.
date: 2009-02
date_type: published
publication: Journal of bioinformatics and computational biology
volume: 7
number: 1
publisher: World Scientific
pagerange: 93-105
refereed: TRUE
issn: 0219-7200
official_url: http://www.worldscinet.com/jbcb/07/0701/S0219720009003960.html
related_url_url: http://www.worldscinet.com/jbcb/07/0701/S0219720009003960.html
related_url_type: pub
citation:   Patnaik, Pratap R  (2009) Transient response analysis of the eukaryotic chemosensory system to intra-cellular fluctuations.  Journal of bioinformatics and computational biology, 7 (1).  pp. 93-105.  ISSN 0219-7200