title: Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione.
creator: Kumar, Akhilesh
creator: Tikoo, Shweta
creator: Maity, Shuvadeep
creator: Sengupta, Shantanu
creator: Sengupta, Sagar
creator: Kaur, Amandeep
creator: Kumar Bachhawat, Anand
subject: QR Microbiology
description: ChaC1 is a mammalian proapoptic protein of unknown function induced during endoplasmic reticulum stress. We show using in vivo studies and novel in vitro assays that the ChaC family of proteins function as γ-glutamyl cyclotransferases acting specifically to degrade glutathione but not other γ-glutamyl peptides. The overexpression of these proteins (but not the catalytically dead E>Q mutants) led to glutathione depletion and enhanced apoptosis in yeast. The ChaC family is conversed across all phyla and represents a new pathway for glutathione degradation in living cells, and the first cytosolic pathway for glutathione degradation in mammalian cells.
publisher: Nature publishing group
date: 2012-11-30
type: Article
type: PeerReviewed
format: application/pdf
identifier: http://crdd.osdd.net/open/1217/1/bachhawat2012.1.pdf
relation: http://www.nature.com/embor/journal/v13/n12/full/embor2012156a.html
identifier:   Kumar, Akhilesh and Tikoo, Shweta and Maity, Shuvadeep and Sengupta, Shantanu and Sengupta, Sagar and Kaur, Amandeep and Kumar Bachhawat, Anand  (2012) Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione.  EMBO reports, 13 (12).  pp. 1095-101.  ISSN 1469-3178     
relation: http://crdd.osdd.net/open/1217/