<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione."^^ . "ChaC1 is a mammalian proapoptic protein of unknown function induced during endoplasmic reticulum stress. We show using in vivo studies and novel in vitro assays that the ChaC family of proteins function as γ-glutamyl cyclotransferases acting specifically to degrade glutathione but not other γ-glutamyl peptides. The overexpression of these proteins (but not the catalytically dead E>Q mutants) led to glutathione depletion and enhanced apoptosis in yeast. The ChaC family is conversed across all phyla and represents a new pathway for glutathione degradation in living cells, and the first cytosolic pathway for glutathione degradation in mammalian cells."^^ . "2012-11-30" . . "13" . "12" . . "Nature publishing group"^^ . . . "EMBO reports"^^ . . . "14693178" . . . . . . . . . . . . . . . . . . . . . . . . . "Sagar"^^ . "Sengupta"^^ . "Sagar Sengupta"^^ . . "Shantanu"^^ . "Sengupta"^^ . "Shantanu Sengupta"^^ . . "Shuvadeep"^^ . "Maity"^^ . "Shuvadeep Maity"^^ . . "Amandeep"^^ . "Kaur"^^ . "Amandeep Kaur"^^ . . "Shweta"^^ . "Tikoo"^^ . "Shweta Tikoo"^^ . . "Anand"^^ . "Kumar Bachhawat"^^ . "Anand Kumar Bachhawat"^^ . . "Akhilesh"^^ . "Kumar"^^ . "Akhilesh Kumar"^^ . . . . . . "Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione. (PDF)"^^ . . . . . "Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione. (Other)"^^ . . . . . . "Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione. (Other)"^^ . . . . . . "Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione. (Other)"^^ . . . . . . "Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione. (Other)"^^ . . . . . . "Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione. (Other)"^^ . . . . . "HTML Summary of #1217 \n\nMammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione.\n\n" . "text/html" . . . "QR Microbiology"@en . .