TY  - JOUR
N1  - Copyright of this article belongs to NPG.
ID  - open1217
UR  - http://www.nature.com/embor/journal/v13/n12/full/embor2012156a.html
IS  - 12
A1  - Kumar, Akhilesh
A1  - Tikoo, Shweta
A1  - Maity, Shuvadeep
A1  - Sengupta, Shantanu
A1  - Sengupta, Sagar
A1  - Kaur, Amandeep
A1  - Kumar Bachhawat, Anand
Y1  - 2012/11/30/
N2  - ChaC1 is a mammalian proapoptic protein of unknown function induced during endoplasmic reticulum stress. We show using in vivo studies and novel in vitro assays that the ChaC family of proteins function as ?-glutamyl cyclotransferases acting specifically to degrade glutathione but not other ?-glutamyl peptides. The overexpression of these proteins (but not the catalytically dead E>Q mutants) led to glutathione depletion and enhanced apoptosis in yeast. The ChaC family is conversed across all phyla and represents a new pathway for glutathione degradation in living cells, and the first cytosolic pathway for glutathione degradation in mammalian cells.
PB  - Nature publishing group
JF  - EMBO reports
VL  - 13
KW  - apoptosis; ChaC1; ?-glutamyl cyclotransferases       
SN  - 1469-3178
TI  - Mammalian proapoptotic factor ChaC1 and its homologues function as ?-glutamyl cyclotransferases acting specifically on glutathione.
SP  - 1095
EP  - 101
ER  -