creators_name: Kumar, Akhilesh
creators_name: Tikoo, Shweta
creators_name: Maity, Shuvadeep
creators_name: Sengupta, Shantanu
creators_name: Sengupta, Sagar
creators_name: Kaur, Amandeep
creators_name: Kumar Bachhawat, Anand
type: article
datestamp: 2013-01-31 06:07:30
lastmod: 2013-01-31 06:07:30
metadata_visibility: show
title: Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione.
ispublished: pub
subjects: QR
keywords: apoptosis; ChaC1; γ-glutamyl cyclotransferases       
note: Copyright of this article belongs to NPG.
abstract: ChaC1 is a mammalian proapoptic protein of unknown function induced during endoplasmic reticulum stress. We show using in vivo studies and novel in vitro assays that the ChaC family of proteins function as γ-glutamyl cyclotransferases acting specifically to degrade glutathione but not other γ-glutamyl peptides. The overexpression of these proteins (but not the catalytically dead E>Q mutants) led to glutathione depletion and enhanced apoptosis in yeast. The ChaC family is conversed across all phyla and represents a new pathway for glutathione degradation in living cells, and the first cytosolic pathway for glutathione degradation in mammalian cells.
date: 2012-11-30
date_type: published
publication: EMBO reports
volume: 13
number: 12
publisher: Nature publishing group
pagerange: 1095-101
refereed: TRUE
issn: 1469-3178
official_url: http://www.nature.com/embor/journal/v13/n12/full/embor2012156a.html
related_url_url: http://www.nature.com/embor/journal/v13/n12/full/embor2012156a.html
related_url_type: org
citation:   Kumar, Akhilesh and Tikoo, Shweta and Maity, Shuvadeep and Sengupta, Shantanu and Sengupta, Sagar and Kaur, Amandeep and Kumar Bachhawat, Anand  (2012) Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione.  EMBO reports, 13 (12).  pp. 1095-101.  ISSN 1469-3178     
document_url: http://crdd.osdd.net/open/1217/1/bachhawat2012.1.pdf