%A Pratap R Patnaik
%O Copyright of this article belongs to OPU.
%J Bioinformatics (Oxford, England)
%T Robustness analysis of the E. coli chemosensory system to perturbations in chemoattractant concentrations.
%X MOTIVATION: Cells of Escherichia coli sense and move toward chemical attractants. This is done through an intricate sensory system that eventually directs the movements of flagellae which regulate the 'runs' and 'tumbles' of the cells. Under realistic conditions, chemical stimuli often fluctuate due to noise from the environment. The effect of noise on the chemosensory system has been investigated here through the sensitivity coefficients of the concentrations of four key proteins--the phosphorylated forms of CheA, CheB and CheY, and the FliM-CheY-P complex--that govern chemotactic motility. The letter P denotes phosphorylation. RESULTS: All sensitivities increased with time and then stabilized. However, the four sets of sensitivities differed in their magnitudes and the durations of their transient phases before stabilization. CheA-P was the least sensitive and CheY-P the most sensitive. Moreover, while the sensitivities of CheA-P, CheB-P and CheY-P increased with chemoattractant concentration, that of the FliM complex decreased. These differences have been interpreted in terms of the mechanism of the chemosensory system and they have important implications for practical applications of chemotaxis.
%N 7
%P 875-81
%V 23
%D 2007
%I Oxford University Press
%L open122