<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Differential expression of NF-kappaB in mycobacteria infected THP-1 affects apoptosis."^^ . "The present study was conducted to see the role of NF-kappaB in virulent (Mycobacterium tuberculosis H37Rv) and avirulent (M. tuberculosis H37Ra) mycobacterial infection in THP-1 cells. To inactivate NF-kappaB, pCMV-IkappaBalphaM dn containing THP-1 cell line was generated which showed marked increase in apoptosis with M. tuberculosis H37Rv and M. tuberculosis H37Ra. Infected THP-1-IkappaBalphaM dn cells showed decrease in mitochondrial membrane potential, cytochrome c release, activation of caspase-3 and enhanced TNF-alpha production. Increase in apoptosis of infected THP-1-IkappaBalphaM dn cells resulted in inhibition of intracellular mycobacterial growth. Differential NF-kappaB activation potential was observed with M. tuberculosis H37Rv and M. tuberculosis H37Ra. Both the strains activated NF-kappaB after 4 h in THP-1 cells however after 48 h only M. tuberculosis H37Rv activated NF-kappaB which lead to up-regulation of bcl-2 family anti-apoptotic member, bfl-1/A1. Our results indicated that NF-kappaB activation may be a determinant factor for the success of virulent mycobacteria within macrophages."^^ . "2007-04" . . "1770" . "4" . . "Elsevier Science"^^ . . . "Biochimica et biophysica acta"^^ . . . "00063002" . . . . . . . . . . . . . "Sekhar"^^ . "Majumdar"^^ . "Sekhar Majumdar"^^ . . "Manoj"^^ . "Raje"^^ . "Manoj Raje"^^ . . "Rohan"^^ . "Dhiman"^^ . "Rohan Dhiman"^^ . . . . . . "Differential expression of NF-kappaB in mycobacteria infected THP-1 affects apoptosis. (PDF)"^^ . . . . . "Differential expression of NF-kappaB in mycobacteria infected THP-1 affects apoptosis. (Image (PNG))"^^ . . . . . . "Differential expression of NF-kappaB in mycobacteria infected THP-1 affects apoptosis. (Image (PNG))"^^ . . . . . . "Differential expression of NF-kappaB in mycobacteria infected THP-1 affects apoptosis. (Image (PNG))"^^ . . . . . . "Differential expression of NF-kappaB in mycobacteria infected THP-1 affects apoptosis. (Image (PNG))"^^ . . . . . . "Differential expression of NF-kappaB in mycobacteria infected THP-1 affects apoptosis. (Indexer Terms)"^^ . . . . . "HTML Summary of #125 \n\nDifferential expression of NF-kappaB in mycobacteria infected THP-1 affects apoptosis.\n\n" . "text/html" . . . "QD Chemistry"@en . .