@article{open1254, volume = {7}, number = {4}, author = {Vijaya Bharathi Srinivasan and Vasanth Vaidyanathan and Amitabha Mondal and Govindan Rajamohan}, note = {OPEN ACCESS}, title = {Role of the two component signal transduction system CpxAR in conferring cefepime and chloramphenicol resistance in Klebsiella pneumoniae NTUH-K2044.}, publisher = {PLOS One}, year = {2012}, journal = {PloS one}, pages = {e33777}, keywords = {Anti-Bacterial Agents; Microbial Sensitivity Tests; Oxidative Stress}, url = {http://crdd.osdd.net/open/1254/}, abstract = {Klebsiella pneumoniae is a gram-negative, non-motile, facultative anaerobe belonging to the Enterobacteriaceae family of the {\ensuremath{\gamma}}-Proteobacteria class in the phylum Proteobacteria. Multidrug resistant K. pneumoniae have caused major therapeutic problems worldwide due to emergence of extended-spectrum {\ensuremath{\beta}}-lactamase producing strains. Two-component systems serve as a basic stimulus-response coupling mechanism to allow organisms to sense and respond to changes in many different environmental conditions including antibiotic stress.} }