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primary topic: Plasma gelsolin: a general prognostic marker of health.

Plasma gelsolin: a general prognostic marker of health.
type: AcademicArticle
type: Article
abstract: Plasma gelsolin (pGSN) is the only component of two member extracellular actin scavenger system capable of severing circulating actin microfilaments. Here, we put forth the hypothesis that pGSN level is an important and sensitive general prognostic biomarker for health and disease conditions in humans, urging the need for gelsolin replacement therapy to improve patient's health status. Clinical significance and the therapeutic importance of this protein have been well illustrated in animal models as well as in patients with various diseases. Patients with decreased pGSN levels were observed to have higher mortality rate, longer hospital stay and longer ventilation time in intensive care units as compared to healthy controls. pGSN levels were found to be increasing in patients recovering from diseases; furthermore, it has been confirmed that repletion with exogenous recombinant pGSN increases the survival rate in animal models of different acute insults. To be used as a biomarker of health, however, establishing the accurate levels of gelsolin in human plasma and understanding its variance with age, race, gender and health status is a prerequisite. Upon establishing the accurate levels of pGSN in healthy individuals, this biomarker would predict the prognosis/disease progression in multiple health conditions and help in prioritizing the ones in-need of gelsolin replacement therapy.
date: 2012-02
volume: 78
issue: 2
is part of: Medical hypotheses
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Plasma gelsolin: a general prognostic marker of health. (PDF)
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has document: Plasma gelsolin: a general prognostic marker of health. (Other)
subject: QR Microbiology

Plasma gelsolin: a general prognostic marker of health. (PDF)
type: Document

Elsevier Science
type: Organization

Medical hypotheses
type: Collection
issn: 15322777

Amin Sagar
type: Person
given name: Amin
family name: Sagar

Ashish Ganguly
type: Person
given name: Ashish
family name: Ganguly

Renu Garg
type: Person
given name: Renu
family name: Garg

Nagesh Peddada
type: Person
given name: Nagesh
family name: Peddada

Plasma gelsolin: a general prognostic marker of health. (Other)
type: Document
is version of: Plasma gelsolin: a general prognostic marker of health. (PDF)
is volatile version of: Plasma gelsolin: a general prognostic marker of health. (PDF)
is index codes version of: Plasma gelsolin: a general prognostic marker of health. (PDF)

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primary topic: Plasma gelsolin: a general prognostic marker of health.

QR Microbiology
type: Concept