%0 Journal Article
%@ 0009-9104
%A Sharma, S
%A Chopra, Kanwaljit
%A Kulkarni, S K
%A Agrewala, J N
%D 2007
%F open:129
%I Wiley
%J Clinical and experimental immunology
%K CD28, CD40, CD80, CTLA-4, curcumin, IL-10, resveratrol
%N 1
%P 155-63
%T Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway.
%U http://crdd.osdd.net/open/129/
%V 147
%X The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)-10.
%Z Copyright of this article belongs to Wiley.