TY  - JOUR
ID  - open129
UR  - http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2249.2006.03257.x/pdf
IS  - 1
A1  - Sharma, S
A1  - Chopra, Kanwaljit
A1  - Kulkarni, S K
A1  - Agrewala, J N
N2  - The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)-10.
VL  - 147
TI  - Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway.
AV  - restricted
EP  - 63
N1  - Copyright of this article belongs to Wiley.
Y1  - 2007/01//
PB  - Wiley
JF  - Clinical and experimental immunology
KW  - CD28
KW  -  CD40
KW  -  CD80
KW  -  CTLA-4
KW  -  curcumin
KW  -  IL-10
KW  -  resveratrol
SN  - 0009-9104
SP  - 155
ER  -