%A S Sharma
%A Kanwaljit Chopra
%A S K Kulkarni
%A J N Agrewala
%O Copyright of this article belongs to Wiley.
%J Clinical and experimental immunology
%T Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway.
%X The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)-10.
%N 1
%K CD28, CD40, CD80, CTLA-4, curcumin, IL-10, resveratrol
%P 155-63
%V 147
%D 2007
%I Wiley
%L open129