creators_name: Sheokand, Navdeep
creators_name: Kumar, Santosh
creators_name: Malhotra, Himanshu
creators_name: Tillu, Vikas
creators_name: Raje, Chaaya Iyengar
creators_name: Raje, Manoj
type: article
datestamp: 2013-06-24 11:33:59
lastmod: 2013-07-18 04:34:22
metadata_visibility: show
title: Secreted glyceraldehye-3-phosphate dehydrogenase is a multifunctional autocrine transferrin receptor for cellular iron acquisition.
ispublished: pub
subjects: QR
note: Copyright of this article belongs to Elsevier Science.
abstract: The long held view is that mammalian cells obtain transferrin (Tf) bound iron utilizing specialized membrane anchored receptors. Here we report that, during increased iron demand, cells secrete the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) which enhances cellular uptake of Tf and iron.
date: 2013-06
date_type: published
publication: Biochimica et biophysica acta
volume: 1830
number: 6
publisher: Elsevier Science
pagerange: 3816-27
refereed: TRUE
issn: 0006-3002
official_url: http://www.sciencedirect.com/science/article/pii/S0304416513000974
citation:   Sheokand, Navdeep and Kumar, Santosh and Malhotra, Himanshu and Tillu, Vikas and Raje, Chaaya Iyengar and Raje, Manoj  (2013) Secreted glyceraldehye-3-phosphate dehydrogenase is a multifunctional autocrine transferrin receptor for cellular iron acquisition.  Biochimica et biophysica acta, 1830 (6).  pp. 3816-27.  ISSN 0006-3002     
document_url: http://crdd.osdd.net/open/1293/1/manojraje13.pdf