%0 Journal Article
%@ 1752-153X
%A Singla, Deepak
%A Tewari, Rupinder
%A Kumar, Ashwani
%A Raghava, G.P.S.
%D 2013
%F open:1304
%I BioMedCentral
%J Chemistry Central journal
%N 1
%P 49
%T Designing of inhibitors against drug tolerant Mycobacterium tuberculosis (H37Rv).
%U http://crdd.osdd.net/open/1304/
%V 7
%X Mycobacterium tuberculosis (M.tb) is the causative agent of tuberculosis, killing ~1.7 million people annually. The remarkable capacity of this pathogen to escape the host immune system for decades and then to cause active tuberculosis disease, makes M.tb a successful pathogen. Currently available anti-mycobacterial therapy has poor compliance due to requirement of prolonged treatment resulting in accelerated emergence of drug resistant strains. Hence, there is an urgent need to identify new chemical entities with novel mechanism of action and potent activity against the drug resistant strains.
%Z OPEN ACCESS