@article{open147,
          volume = {50},
          number = {7},
           month = {July},
          author = {Vijaya Bharathi Srinivasan and Rupinder Kaur Virk and Amita Kaundal and Rupa Chakraborty and Basabjit Datta and T Ramamurthy and A K Mukhopadhyay and Amit Ghosh},
            note = {Copyright of this article belongs to ASM.},
           title = {Mechanism of drug resistance in clonally related clinical isolates of Vibrio fluvialis isolated in Kolkata, India.},
       publisher = {ASM},
            year = {2006},
         journal = {Antimicrobial agents and chemotherapy},
           pages = {2428--32},
             url = {http://crdd.osdd.net/open/147/},
        abstract = {The molecular mechanisms of drug resistance in 19 strains of Vibrio fluvialis isolated from 1998 to 2002 in Kolkata, India, were investigated. Class 1 integrons were detected in eight strains, and four strains were found to carry SXT integrases. In the presence of carbonyl cyanide m-chlorophenylhydrazone or reserpine, all nalidixic acid- and ciprofloxacin-resistant strains became sensitive, suggesting that drug efflux plays a major role in quinolone resistance in V. fluvialis. It was further seen that strains which had MICs of {\ensuremath{>}} 25 microg/ml for nalidixic acid had a sense mutation (Ser to Ile) at position 83 of the quinolone resistance-determining region of gyrA. All except one of the integron- and SXT integrase-bearing strains belonged to the same ribotype.}
}