%0 Journal Article
%@ 0066-4804
%A Srinivasan, Vijaya Bharathi
%A Virk, Rupinder Kaur
%A Kaundal, Amita
%A Chakraborty, Rupa
%A Datta, Basabjit
%A Ramamurthy, T
%A Mukhopadhyay, A K
%A Ghosh, Amit
%D 2006
%F open:147
%I ASM
%J Antimicrobial agents and chemotherapy
%N 7
%P 2428-32
%T Mechanism of drug resistance in clonally related clinical isolates of Vibrio fluvialis isolated in Kolkata, India.
%U http://crdd.osdd.net/open/147/
%V 50
%X The molecular mechanisms of drug resistance in 19 strains of Vibrio fluvialis isolated from 1998 to 2002 in Kolkata, India, were investigated. Class 1 integrons were detected in eight strains, and four strains were found to carry SXT integrases. In the presence of carbonyl cyanide m-chlorophenylhydrazone or reserpine, all nalidixic acid- and ciprofloxacin-resistant strains became sensitive, suggesting that drug efflux plays a major role in quinolone resistance in V. fluvialis. It was further seen that strains which had MICs of > 25 microg/ml for nalidixic acid had a sense mutation (Ser to Ile) at position 83 of the quinolone resistance-determining region of gyrA. All except one of the integron- and SXT integrase-bearing strains belonged to the same ribotype.
%Z Copyright of this article belongs to ASM.